Rheumatoid Arthritis: Symptoms, Causes, and Related Conditions
What is Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that primarily affects the synovial joints. Unlike osteoarthritis, which results from mechanical wear, RA is driven by an immune-mediated attack on the joint lining, leading to inflammation, cartilage damage, and bone erosion.
RA affects around 0.5–1% of the global population, with higher prevalence in women. It is usually diagnosed between ages 30–60, though it can occur at any age.
Physiological Processes and Current Theories
The exact cause of RA is not fully understood, but current research highlights a combination of genetic predisposition, immune dysregulation, and environmental triggers:
Immune activation: In RA, T-cells and B-cells mistakenly target the synovium (joint lining). This leads to chronic inflammation and the release of pro-inflammatory cytokines (TNF-α, IL-1, IL-6).
Synovial proliferation (pannus formation): The inflamed synovium thickens and invades cartilage and bone, causing erosion and deformity.
Autoantibodies: Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are hallmarks of RA. They appear years before clinical symptoms and contribute to systemic inflammation.
Genetic risk: Variants in HLA-DRB1 (“shared epitope” alleles) are strongly linked to disease development.
Environmental triggers: Smoking, infections, and possibly alterations in the gut microbiome are implicated in disease onset.
RA is increasingly viewed as a systemic disease, not just a joint disorder. Chronic inflammation contributes to complications in the cardiovascular, pulmonary, and metabolic systems.
Common Symptoms
Persistent joint pain, swelling, and stiffness, especially in small joints of the hands and feet
Morning stiffness lasting longer than 30 minutes
Warmth and tenderness around joints
Fatigue and low energy
Symmetrical joint involvement
Less Common Symptoms
Low-grade fever during active flares
Rheumatoid nodules (firm lumps under the skin, usually near elbows or fingers)
Peripheral neuropathy
Eye inflammation (scleritis, episcleritis)
Lung involvement (pleuritis, interstitial lung disease)
Comorbidities and Systemic Features
RA is associated with several comorbidities, many linked to long-term systemic inflammation:
Cardiovascular disease (increased risk of heart attack and stroke)
Osteoporosis (due to inflammation, reduced mobility, and corticosteroid use)
Interstitial lung disease (occurs in up to 10% of RA patients)
Depression and anxiety, often related to chronic pain and disability
Metabolic syndrome and insulin resistance
Secondary Sjögren’s syndrome (dry eyes, dry mouth)
Diagnosis
Diagnosis is made by a rheumatologist, based on clinical examination, blood tests, and imaging:
Blood markers: Rheumatoid factor (RF), anti-CCP (ACPA), ESR, CRP
Imaging: Ultrasound and MRI detect early synovitis and bone marrow edema before X-ray changes appear
Classification criteria: The 2010 ACR/EULAR criteria remain standard, with emphasis on early detection before structural damage develops
In recent years, there has been a push for early diagnosis and intervention, as treating RA aggressively within the first 3–6 months can alter long-term disease trajectory.
Current State of Knowledge
RA is now recognised as a treatable but not curable autoimmune disease. Modern therapies (biologics, targeted synthetic DMARDs) have dramatically reduced rates of disability and joint deformity compared to past decades.
Research continues into:
Personalised medicine: tailoring biologic choice (TNF inhibitors, IL-6 blockers, JAK inhibitors) based on biomarkers
Microbiome links: how gut dysbiosis may influence immune activation
Remission strategies: identifying patients who can taper medications while maintaining disease control
If you are living with rheumatoid arthritis in Cork and want to understand evidence-based options for care and rehabilitation, read more about rheumatoid arthritis treatment here.
Rheumatoid Arthritis Treatment and Rehabilitation in Cork
International Standards of Care
Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires a multidisciplinary approach. International guidelines (EULAR 2023, ACR 2022, BSR 2023) emphasise early diagnosis and aggressive treatment to control inflammation, protect joints, and reduce disability.
The recommended pillars of care are:
Disease-modifying medication prescribed and monitored by a rheumatologist
Specialist physiotherapy and exercise-based rehabilitation
Joint protection strategies and pacing to support daily life
Psychological and lifestyle interventions to reduce stress and build resilience
Somatic and mind–body practices to regulate the nervous system and improve coping
Medical Management
The medical cornerstone of RA is the use of disease-modifying anti-rheumatic drugs (DMARDs). These slow or halt disease progression and reduce joint damage.
Methotrexate remains the first-line conventional DMARD.
Biologics (TNF inhibitors, IL-6 blockers, B-cell therapies) are highly effective for patients with persistent activity.
JAK inhibitors are an emerging oral option where biologics are not suitable.
Corticosteroids may be used short-term for flares.
Medication controls inflammation, but it cannot maintain strength, mobility, or daily independence on its own. That is where rehabilitation becomes critical.
Exercise and Physiotherapy in RA
Exercise in RA is about more than general fitness. It is about protecting function and independence in the face of fluctuating symptoms and long-term risk of disability.
Research shows that tailored exercise:
Preserves range of motion in affected joints
Builds muscle strength to reduce load on inflamed joints
Improves cardiovascular health, addressing the increased CV risk in RA
Reduces fatigue and improves energy levels
Enhances fine motor control and dexterity, especially in the hands
The challenge for patients is knowing how to exercise during flares versus during remission. Many avoid movement out of fear of worsening inflammation, while others push too hard and pay for it with pain and swelling. Both patterns create setbacks.
This is why professional guidance matters. A specialised physiotherapist can:
Teach joint protection principles (avoiding positions that overstress inflamed joints, using assistive strategies when needed)
Guide you in low-load strengthening and range of motion exercises that preserve mobility
Provide hand therapy strategies to protect grip and dexterity
Adapt exercise intensity according to flare or remission status
Help you integrate pacing so movement becomes sustainable rather than draining
With the right guidance, exercise becomes a tool not just for the body but for confidence and independence.
Somatic and Mind–Body Approaches
RA is not only about inflamed joints. It is also about living with unpredictable flares, fatigue, and the mental strain of planning life around symptoms. This is where somatic and mind–body practices make a difference.
Yoga therapy supports flexibility and posture, and improves balance between strength and mobility.
Mindfulness and meditation change the way the brain processes pain, reducing emotional distress linked to flare cycles.
Guided relaxation and breathwork reduce sympathetic overactivation, helping with fatigue and sleep recovery.
Body awareness practices restore confidence in movement, reduce guarding, and allow patients to reconnect with safe and efficient patterns.
These practices complement medical and physical treatments, addressing the nervous system and the psychological burden of RA.
Psychological and Lifestyle Support
CBT helps patients reframe pain and build healthier behaviour patterns.
ACT helps people continue living in line with what matters most to them, even when symptoms remain.
Nutrition: Evidence supports anti-inflammatory dietary approaches, often Mediterranean in style, for both general health and cardiovascular risk reduction.
Sleep restoration: Essential for fatigue management and immune regulation.
Rehabilitation at Neurokinetica
At Neurokinetica, we understand that rheumatoid arthritis is not just about swollen joints. It is about mornings where your hands feel too stiff to open a jar, days where fatigue keeps you from doing what you planned, and the fear that flares or deformities could take away your independence.
We work with you to protect what matters most: your ability to move, work, and live with confidence. Our programmes combine:
Targeted physiotherapy and exercise tailored to joint protection and mobility
Hand-specific strategies and strengthening to maintain dexterity
Yoga-based movement, breathwork, and guided relaxation to reduce stiffness and support nervous system balance
Education on pacing and joint protection so you can stay active without worsening flares
Step-by-step guidance until you feel confident in managing your condition independently
Patients often tell us they leave sessions not only moving better but also feeling clearer, calmer, and more in control of their health.
Our goal is not just short-term relief. It is to help you build the skills, strength, and confidence to live more fully with rheumatoid arthritis.
If you are searching for rheumatoid arthritis treatment in Cork, and want a tailored approach that combines medical knowledge, exercise therapy, and nervous system regulation, book a session to get an assessment and learn about rehabilitation with us.