Chronic Pain: Symptoms, Causes, and Related Conditions

Chronic pain and chronic fatigue management in Cork - through exercise-based physiotherapy and nervous system regulation through therapeutic yoga. Yoga for chronic pain in Cork. Exercise for chronic pain in Cork.

What is Chronic Musculoskeletal Pain?

Chronic musculoskeletal pain is pain that persists for longer than three months in muscles, joints, ligaments, or connective tissue. Unlike acute pain, which signals tissue injury and usually resolves with healing, chronic pain often continues without clear ongoing damage.

It is not “imagined” pain. It reflects real changes in the way the nervous system processes information, making pain more persistent and more widespread than the original injury would suggest.

Chronic musculoskeletal pain is common, affecting around 20% of adults. It includes back pain, neck pain, and generalised pain syndromes where no single structural diagnosis explains the severity of symptoms.

Physiological Processes and Pain Neuroscience

Modern pain science shows that chronic pain is not just a problem of the muscles or joints. It is a system-wide issue involving the nervous system, immune system, and brain.

  • Sensitisation: Nerves become more sensitive, sending stronger danger signals to the brain.

  • Central amplification: The spinal cord and brain amplify incoming signals, turning normal sensations into pain.

  • Neuroimmune interactions: Immune cells release inflammatory chemicals that change how nerves fire.

  • Altered interoception: Interoception is the brain’s sense of the body’s internal state. In chronic pain, interoception becomes distorted — normal signals of tension, stretch, or fatigue may be misread as threatening.

  • Protective output: Pain is the brain’s protective response. Louis Gifford described this as “sensitive alarm systems” that remain switched on, even when tissues are healed.

Researchers such as David Butler and Lorimer Moseley have shown that pain is an output of the nervous system, not a direct measure of tissue damage. This explains why pain can persist even when scans look normal — and why education, movement, and nervous system retraining are essential.

Common Symptoms

  • Persistent or recurrent muscle or joint pain

  • Stiffness, especially after rest

  • Fatigue and low energy

  • Heightened pain with normally tolerable activity

  • Sleep disturbance due to discomfort

Less Common Symptoms

  • Pain spreading beyond the original area of injury

  • Sensitivity to light, sound, or touch

  • Fluctuating symptoms without clear cause

  • Cognitive symptoms (“brain fog”) linked to pain and fatigue

Comorbidities and Related Conditions

Chronic musculoskeletal pain often overlaps with or contributes to:

  • Fibromyalgia

  • Hypermobility spectrum disorders

  • Chronic fatigue and post-viral syndromes

  • Depression and anxiety

  • Irritable bowel syndrome and other functional somatic syndromes

  • Sleep disorders

Diagnosis in 2025

Diagnosis is clinical, based on the history of pain lasting longer than three months, often beyond the expected healing time of any original injury. It is not diagnosed by MRI or X-ray, which often show age-related changes that do not correlate well with pain.

Clinicians now place more emphasis on identifying pain mechanisms (nociceptive, neuropathic, nociplastic) and ruling out serious pathology. Chronic musculoskeletal pain usually falls into the nociplastic pain category — where the problem lies in altered processing of signals, not ongoing tissue injury.

Current State of Knowledge

Research has moved beyond searching for single structural “causes” of chronic pain. Instead, pain is seen as an emergent property of multiple systems interacting.

  • Neuroplasticity: The brain can change in both directions. Pain pathways can become reinforced, but they can also be retrained.

  • Psychosocial factors: Stress, fear of movement, and low self-efficacy can worsen pain.

  • Movement as therapy: Graded exposure and carefully paced exercise help desensitise the system and restore trust in the body.

  • Education as therapy: Explaining pain science reduces fear and improves outcomes — Moseley and Butler’s work on “Explain Pain” has shown this globally.

Chronic musculoskeletal pain is now recognised as a condition that requires integrative care: medical reassurance, physiotherapy, nervous system regulation, and education that empowers patients to move and live again.

If you are living with chronic musculoskeletal pain in Cork and want to understand how treatment goes beyond short-term fixes, read more about chronic pain treatment and rehabilitation here.

Chronic Pain Treatment and Rehabilitation in Cork

Chronic pain and chronic fatigue management through exercise-based physiotherapy and nervous system regulation through therapeutic yoga. Yoga for chronic pain in Cork. Exercise therapy for chronic pain in Cork.

International Standards of Care

International guidelines (IASP, NICE 2021, European Pain Federation) agree that chronic musculoskeletal pain is best managed with a multimodal approach. Medication alone does little. The gold standard is a combination of:

  • Patient education and pain neuroscience understanding

  • Exercise and physiotherapy to restore confidence in movement

  • Somatic and mind–body practices that target the nervous system directly

  • Psychological support to address fear, stress, and coping

  • Lifestyle interventions around sleep, stress, and activity pacing

The focus is not on “curing pain” but on restoring function, confidence, and quality of life.

Medical Management

Doctors may prescribe medications such as:

  • Neuropathic pain agents (duloxetine, pregabalin)

  • Short courses of NSAIDs for flare-ups

  • Occasional low-dose antidepressants for sleep or pain modulation

But evidence shows these medications have only modest benefit in chronic pain, and they work best as an adjunct to rehabilitation and self-management.

Exercise and Physiotherapy

Louis Gifford’s work emphasised that in chronic pain, the system is overprotective, not necessarily damaged. Muscles may be tight, joints may feel fragile, but the real issue is that the nervous system is amplifying normal signals.

Exercise works because it recalibrates this system:

  • Movement provides the nervous system with new, non-threatening input.

  • Graded exposure reduces fear by proving that safe movement does not equal harm.

  • Strengthening builds tissue resilience, reducing the risk of flare-ups from everyday tasks.

  • Aerobic exercise improves blood flow, endorphin release, and immune modulation.

But the difference lies in how exercise is delivered. Generic “just go to the gym” advice often backfires — patients push too hard, flare, and lose trust in their bodies. A skilled physiotherapist guides you in finding the right entry point, pacing progress so you build capacity without setbacks. This process restores not only function but also confidence.

Pain Neuroscience Education

David Butler and Lorimer Moseley’s work has shown that when people understand that pain is an output of the nervous system, not a measure of damage, fear decreases and recovery improves. Education is not an “extra.” It changes the brain’s interpretation of signals, making every other intervention more effective.

At Neurokinetica, pain neuroscience is woven into treatment. You learn why your pain persists, how the nervous system creates protective responses, and most importantly, how to retrain it. Patients often describe this knowledge as the moment everything “clicks.”

Somatic and Mind–Body Practices

This is where chronic pain rehabilitation has changed most in the past decade. Research now confirms that practices like yoga, mindfulness, and somatic methods such as Feldenkrais are not “alternative” but evidence-based tools for pain management.

Why they work:

  • They improve interoception: the brain’s ability to interpret internal signals. In chronic pain, interoception is often distorted — normal muscle tension or fatigue is misread as danger. Somatic practices retrain this perception, teaching the nervous system to feel safe again.

  • They reduce sympathetic overdrive: Chronic pain keeps the body in fight-or-flight mode. Breathwork, mindfulness, and guided relaxation activate the parasympathetic system, allowing recovery and repair.

  • They re-establish movement variability: Feldenkrais and similar methods explore gentle, novel movements that give the nervous system new options, breaking rigid, protective patterns.

  • They target both mind and body together, reducing not only pain intensity but also fear, anxiety, and fatigue.

Evidence:

  • Clinical trials show yoga reduces pain intensity, improves function, and lowers psychological distress in chronic back and neck pain.

  • Feldenkrais-based interventions improve movement efficiency, proprioception, and perceived pain in long-term musculoskeletal conditions.

  • Mindfulness-based stress reduction (MBSR) reduces pain interference and improves mood in chronic pain populations.

These are not “relaxation add-ons.” They are central strategies that directly modulate the pain system.

Psychological and Lifestyle Support

Chronic pain is sustained not only by biological processes but also by stress, sleep disruption, and unhelpful coping patterns.

  • CBT improves function by changing pain-related thoughts and behaviours.

  • ACT helps patients commit to valued activities even with ongoing symptoms.

  • Sleep optimisation is crucial, since poor sleep heightens pain sensitivity.

  • Stress management reduces immune and nervous system overactivation.

Rehabilitation at Neurokinetica

At Neurokinetica, we understand that chronic musculoskeletal pain is not about a “bad back” or a “dodgy knee.” It is about a nervous system that has learned to stay on high alert, making every movement feel risky. Patients often tell us they feel stuck between avoiding activity out of fear and pushing too hard only to pay for it later.

Our approach is designed to break that cycle. We help you:

  • Understand your pain through clear, science-based education

  • Rebuild confidence with graded, tailored exercise that strengthens without flaring

  • Explore safe, novel movements through yoga-based therapy and somatic practices like Feldenkrais

  • Use breathwork and relaxation to regulate your nervous system and reduce background stress

  • Develop pacing strategies so energy is spread more evenly across your days

  • Build long-term resilience, so you are not dependent on short-term fixes

Patients often leave sessions not just with less pain, but with a sense of clarity — finally understanding why their pain persists and how to move forward. Over time, they regain not only mobility but also the trust that their body is capable of more than they thought possible.

Our goal is not temporary relief. It is to give you the knowledge, skills, and physical and nervous system capacity to live more fully with less pain.

If you are seeking chronic pain treatment in Cork, and want a professional approach that combines pain neuroscience, exercise, and somatic rehabilitation, book a session to get an assessment and learn more about our programmes.