Axial Spondyloarthritis: Symptoms, Causes, and Related Conditions
What is Axial Spondyloarthritis?
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints. It is part of the spondyloarthritis family, which includes psoriatic arthritis and reactive arthritis.
AxSpA is an umbrella term that includes:
Non-radiographic axial spondyloarthritis (nr-axSpA): inflammation is present, but changes are not yet visible on X-rays.
Ankylosing spondylitis (AS): structural damage is visible on X-rays, often with new bone formation and spinal fusion.
Research up to 2025 recognises axSpA as a systemic immune-mediated disease driven by both genetic predisposition (especially HLA-B27) and immune dysregulation involving IL-17 and TNF pathways.
Physiological Processes and Current Theories
The underlying process is a chronic immune response that targets the entheses (the sites where tendons and ligaments attach to bone). This “enthesitis” leads to:
Inflammation: Immune cells release cytokines (TNF-α, IL-17, IL-23), producing local and systemic inflammation.
Bone changes: Inflammation stimulates both bone erosion and new bone formation. Over time, this can lead to fusion of vertebrae (ankylosis).
Pain sensitisation: Like other chronic pain conditions, axSpA also involves central sensitisation. The nervous system amplifies pain beyond the structural changes.
Common Symptoms
Chronic back pain and stiffness, especially in the lower back and buttocks
Morning stiffness lasting more than 30 minutes
Pain that improves with movement but worsens with rest
Fatigue and disrupted sleep
Reduced spinal mobility and flexibility
Less Common Symptoms
Alternating buttock pain due to sacroiliac joint inflammation
Peripheral joint involvement (hips, shoulders, knees)
Enthesitis at sites such as the Achilles tendon or plantar fascia
Costochondritis (chest wall pain from rib inflammation)
Eye inflammation (uveitis)
Comorbidities and Extra-Articular Features
AxSpA is not limited to the spine. It frequently overlaps with other conditions:
Uveitis (up to 30–40% of patients over their lifetime)
Inflammatory bowel disease (IBD) such as Crohn’s or ulcerative colitis
Psoriasis
Cardiovascular risk – higher prevalence of hypertension, metabolic syndrome, and atherosclerosis
Osteoporosis due to chronic inflammation and reduced mobility
Depression and anxiety, often linked to chronic pain and fatigue
Diagnosis
Diagnosis of axSpA can still be delayed, but awareness has improved. Criteria now rely on:
Clinical features: chronic back pain starting before age 45, inflammatory pattern of symptoms
Imaging: MRI is key, as it can detect active inflammation before structural changes appear on X-rays
Blood markers: HLA-B27 positivity, elevated CRP or ESR (though some patients test negative)
The ASAS classification criteria (Assessment of SpondyloArthritis International Society) remain the international standard, combining clinical, imaging, and genetic markers.
Current State of Knowledge
AxSpA is recognised as a systemic immune-mediated inflammatory disease, not just a mechanical back disorder. Early recognition and treatment are critical, as modern biologic therapies can significantly slow disease progression if started before irreversible structural changes occur.
Research is ongoing into:
Precision medicine – identifying which patients respond best to TNF inhibitors versus IL-17 inhibitors
Gut–joint axis – the relationship between microbiome alterations and inflammation in axSpA
Long-term outcomes – understanding how early diagnosis and exercise-based rehabilitation can reduce disability over decades
If you are living with axial spondyloarthritis in Cork and want to learn about evidence-based options for care and rehabilitation, read more about treatment for axial spondyloarthritis here.
Axial Spondyloarthritis Treatment and Rehabilitation in Cork
International Standards of Care
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the spine and sacroiliac joints. International guidelines (ASAS-EULAR 2022, BSR 2023, ACR) recommend a treatment approach that combines targeted medication, structured rehabilitation, and long-term self-management.
The key pillars are:
Anti-inflammatory and disease-modifying medication prescribed by rheumatologists
Tailored physiotherapy and structured exercise
Lifestyle and pacing strategies to preserve mobility
Mind–body practices that support resilience and coping
Medical Management
Rheumatologists oversee the medical side of axSpA care. Treatments may include:
NSAIDs as first-line for inflammation and pain
Biologic therapies such as TNF inhibitors or IL-17 inhibitors, which can slow progression and reduce inflammation
JAK inhibitors, an oral option for selected cases
Analgesics and adjunct medications for pain management
Medication is effective at controlling inflammation, but it does not prevent stiffness, loss of mobility, or deconditioning on its own. This is where rehabilitation becomes essential.
Exercise as the Core of Long-Term Management
Unlike fibromyalgia, where exercise helps retrain a hypersensitive nervous system, in axSpA exercise is about protecting movement and preventing stiffness from becoming permanent.
Research shows that regular exercise improves posture, spinal mobility, chest expansion, and overall function. It also lowers cardiovascular risk, which is higher in people with axSpA due to chronic inflammation.
The challenge is not knowing what to do, but knowing how to do it safely and consistently over years. A generic gym programme will not address the unique needs of axSpA. Without guidance, it is easy to neglect spinal extension, breathing mechanics, or pacing — all of which are central to preserving independence.
A specialised physiotherapist can help you:
Maintain extension and upright posture to reduce long-term fusion risk
Strengthen hips, shoulders, and core to support spinal health
Improve breathing mechanics through targeted chest and rib mobility work
Integrate pacing so that fatigue and pain are managed alongside progress
Develop a sustainable home programme that fits into your life
This is not about short bursts of exercise. It is about learning how to keep your spine and body moving in ways that will serve you for decades.
Somatic and Mind–Body Approaches
AxSpA is immune-driven, but it is also shaped by how the nervous system and stress response interact with inflammation and pain. Somatic and mind–body practices complement exercise by supporting whole-body regulation.
Yoga therapy improves flexibility, posture awareness, and spinal mobility while reducing stiffness.
Breathwork directly supports rib cage expansion, which is often limited in axSpA. Techniques such as diaphragmatic breathing improve lung capacity and reduce the feeling of chest tightness.
Guided relaxation and mindfulness reduce the stress response, which can worsen fatigue and inflammation.
Somatic awareness practices help patients reconnect with safe, efficient movement patterns, reducing tension and guarding.
These approaches make exercise more effective by reducing background stress, improving recovery, and reinforcing positive body awareness.
Education, Self-Management, and Coping
Education is a treatment in itself. People with axSpA need to understand how inflammation and stiffness interact, why movement is protective, and how to balance activity with rest.
Psychological support can also play a role:
Cognitive Behavioural Therapy (CBT) helps patients sustain exercise habits and manage pain more effectively.
Acceptance and Commitment Therapy (ACT) supports living in line with personal values, even when symptoms persist.
Rehabilitation at Neurokinetica
At Neurokinetica, we know what it means to live with a spine that feels heavy, stiff, or locked. Many of our patients tell us they feel as though their body is closing in on itself, and they are afraid of what the future holds. We work with those fears directly.
Our approach is built on the principle that movement is not optional in axSpA — it is essential. But not just any movement. We help you build the specific mobility, strength, and breathing patterns that keep your spine open and resilient. We guide you through tailored programmes that protect your joints, support your posture, and improve your breathing mechanics.
Alongside this, we integrate yoga therapy, breathwork, guided relaxation, and mindfulness to reduce stiffness, restore nervous system balance, and make movement feel safe again. Patients often report not only improved flexibility and less pain, but also more energy and confidence in their ability to manage flare cycles.
Our role is to guide you step by step until you can carry these practices into your life with independence. The goal is not just to reduce symptoms but to preserve mobility, strength, and confidence for the long term.
If you are looking for axial spondyloarthritis treatment in Cork and want a tailored approach that combines exercise, breathwork, and specialised physiotherapy, book a session to get assessed and learn more about our rehabilitation.